专利名称：Dendritic Cell Compositions and Methods发明人：Rebecca Pogue-Caley,Tamara
Monesmith,Irina Tcherepanova,LoisDinterman
申请号：US13351510申请日：20120117
公开号：US20120114680A1公开日：20120510
摘要：Methods are provided for the production of dendritic cells from monocytesthat have been incubated at a temperature of 1° C.-34° C. for a period of approximately 6to 96 hours from the time they are isolated from a subject. After the incubation period,the monocytes can then be induced to differentiate into dendritic cells. Mature dendriticcells made by the methods of the invention have increased levels of one or more ofCD80, CD83, CD86, MHC class I molecules, or MHC class II molecules as compared tomature dendritic cells prepared from monocytes that have not been held at 1° C.-34° C.for at least 6 hours from the time they were isolated from a subject. Dendritic cells madeby the methods of the invention are useful for the preparation of vaccines and for thestimulation of T cells.
申请人：Rebecca Pogue-Caley,Tamara Monesmith,Irina Tcherepanova,Lois Dinterman
地址：Durham NC US,Durham NC US,Rougemont NC US,Kearneysville WV US
国籍：US,US,US,US
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