SYNTHETIC QUORUM-REGULATED LYSIS

专利名称：SYNTHETIC QUORUM-REGULATED LYSIS发明人：HASTY, Jeff,TSIMRING, Lev,SCOTT, Spencer,

R.,DIN, Muhammad, Omar

申请号：EP18801861申请日：20180518公开号：EP3625354A4公开日：20210602

摘要：Provided herein are methods of co-culturing by quorum sensing, bacterialstrains useful in co-culture systems and methods, co-culture systems, and pharmaceuticalcompositions, drug delivery systems, and methods of treating disease related thereto. Insome embodiments, the co-lysis systems are provided that operate in an orthogonal oressentially orthogonal manner. In some embodiments, methods of maintaining a co-culture by quorum sensing are provided that include: co-culturing at least two bacterialstrains at certain ratios during a period of time; wherein: at least one of the at least twobacterial strains has a growth advantage compared to at least one other bacterial strain;at least one of the at least two bacterial strains comprises a lysis plasmid and an activatorplasmid. Also provided herein are pharmaceutical composition that include any of thebacterial strains described herein.

申请人：The Regents of the University of California

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