P53-induced apoptosis

专利名称：P53-induced apoptosis发明人：BERT VOGELSTEIN,KENNETH W.

KINZLER,KORNELIA POLYAK

申请号：AU9317398申请日：19980917公开号：AU750187B2公开日：20020711

摘要：The most well-documented biochemical property of p53 is its ability to

transcriptionally activate genes. Many of the genes which are activated by p53 expressionprior to the onset of apoptosis are predicted to encode proteins which could generate orrespond to oxidative stress, including one that is implicated in apoptosis within plantmeristems. p53 may result in apoptosis through a three-step process: (I) the

transcriptional induction of specific redox-related genes; (ii) the formation of reactiveoxygen species (ROS); and (iii) the oxidative degradation of mitochondrial components,rapidly leading to cell death. Transcription of other genes is decreased by p53.

Examination of the level of transcription of p53-induced or, -repressed genes can be usedto determine p53 status, to diagnose cancer, and to evaluate cytotoxicity orcarcinogenicity of a test agent.

申请人：THE JOHNS HOPKINS UNIVERSITY

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